Which of the following is a major risk factor for coronary artery disease?

High cholesterol is recognized as a major risk factor for coronary artery disease due to its role in the development of atherosclerosis. A high level of low-density lipoprotein (LDL) cholesterol can lead to the buildup of plaque in the arteries, which narrows them and restricts blood flow to the heart. This increases the risk of heart attacks and other cardiovascular events.

In contrast, low blood pressure, high physical activity, and normal body weight are generally considered protective factors against coronary artery disease. Low blood pressure often indicates better cardiovascular health, while engaging in regular physical activity contributes to improved heart function and can help maintain healthy cholesterol levels and weight. Maintaining a normal body weight also reduces the overall strain on the heart and minimizes other associated risk factors. Thus, high cholesterol stands out as a significant contributor to the risk for coronary artery disease.